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Retinoblastoma Binding Protein 8 抗体 (AA 620-897)

Name: Retinoblastoma Binding Protein 8 抗体 (AA 620-897)
SKU: ABIN2668263
Availability: OutOfStock

This 小鼠单克隆 antibody specifically detects Retinoblastoma Binding Protein 8 in WB, IF, IP, ICC 和 ChIP. It exhibits reactivity toward 人. It has been mentioned in 6+ publications

(6 references)

产品编号 ABIN2668263

发货至: 中国

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Quick Overview for Retinoblastoma Binding Protein 8 抗体 (AA 620-897) (ABIN2668263)

抗原

See all Retinoblastoma Binding Protein 8 (RBBP8) 抗体

Retinoblastoma Binding Protein 8 (RBBP8)

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This Retinoblastoma Binding Protein 8 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)

克隆位点

14-1

Discover our top product RBBP8 Primary Antibody

抗原表位
13

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1
AA 620-897

原理

CtIP antibody (mAb) (Clone 14-1)

纯化方法

Protein A Chromatography

免疫原

This CtIP antibody was raised against a recombinant protein corresponding to amino acid residues 620-897 of human CtIP.

亚型

IgG1
anti-Retinoblastoma Binding Protein 8 (RBBP8) (AA 452-747) antibody
RBBP8 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) antibody
RBBP8 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) (AA 126-331) antibody
RBBP8 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) (Center) antibody
RBBP8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) (AA 1-300) antibody
RBBP8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) (pThr847) antibody
RBBP8 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) (pSer327) antibody
RBBP8 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) (pSer326) antibody
RBBP8 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) (AA 763-792), (C-Term) antibody
RBBP8 适用: 人 WB 宿主: 兔 Polyclonal RB34059 unconjugated

anti-Retinoblastoma Binding Protein 8 (RBBP8) (AA 686-735) antibody
RBBP8 适用: 人, 猴, Cow, 犬, 兔 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1 - 2 μg/mL

限制

仅限研究用
浓度

1 μg/μL

缓冲液

Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

储存条件

-20 °C

储存方法

Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

有效期

24 months
Onyango, Howard, Neherin, Yanez, Stark: "Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination." in: Nucleic acids research, Vol. 44, Issue 12, pp. 5702-16, (2016) (PubMed).

Bakr, Köcher, Volquardsen, Petersen, Borgmann, Dikomey, Rothkamm, Mansour: "Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1." in: Oncotarget, Vol. 7, Issue 36, pp. 57679-57693, (2016) (PubMed).

Zhou, Caron, Legube, Paull: "Quantitation of DNA double-strand break resection intermediates in human cells." in: Nucleic acids research, Vol. 42, Issue 3, pp. e19, (2014) (PubMed).

Makharashvili, Tubbs, Yang, Wang, Barton, Zhou, Deshpande, Lee, Lobrich, Sleckman, Wu, Paull: "Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection." in: Molecular cell, Vol. 54, Issue 6, pp. 1022-33, (2014) (PubMed).

Zhang, Jasin: "An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway." in: Nature structural & molecular biology, Vol. 18, Issue 1, pp. 80-4, (2011) (PubMed).

Yu, Fu, Lai, Baer, Chen: "BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP." in: Genes & development, Vol. 20, Issue 13, pp. 1721-6, (2006) (PubMed).
抗原

Retinoblastoma Binding Protein 8 (RBBP8)

别名

CtIP

背景

CtIP (CTBP interacting protein, RBBP8, RIM, COM1) is a transcriptional regulator and tumor suppressor first identified through its interaction with CTBP (C-Terminal Binding Protein). CtIP binds to the Rb protein and serves as a transcriptional repressor, through recruitment of CtBP and also by interaction with general transcription factors TFIID and TFIIB. CtIP also interacts with Rb-related protein p130 and Ikaros, a master regulator in lymphocyte development. CtIP is phosphorylated upon DNA damage (likely by ATM and/or ATR), interacts with BRCA1 and plays a critical role in facilitating DNA damage repair. Mutations that abolish the interaction between CtIP and BRCA1 result in loss of cell cycle control leading to the development of cancer.

分子量

120 kDa

基因ID

5932

NCBI登录号

NP_002885

途径

Cell Division Cycle, DNA Damage Repair