BID 抗体
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北京 101111
Quick Overview for BID 抗体 (ABIN2666317)
抗原
See all BID 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography.
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- phosphate-buffered solution, pH 7.2, 0.09 % Sodium azide.
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储存条件
- 4 °C
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储存方法
- Upon receipt, store undiluted between 2°C and 8°C.
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- BID (BH3 Interacting Domain Death Agonist (BID))
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别名
- BID
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背景
- BID, a BH3 interacting domain death agonist is a member of the Bcl-2/Bcl-xL family. BID can form a heterodimer with either agonist BAX or antagonist Bcl-2. It is a mediator of mitochondrial damage induced by Caspase-8 (CASP8). After the cleavage by CASP8, the COOH-terminal part translocates to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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