RAD23B 抗体
Quick Overview for RAD23B 抗体 (ABIN2666305)
抗原
See all RAD23B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Protein G affinity purified.
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亚型
- IgG1 lambda
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anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibody
RAD23B 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 50-150) antibodyRAD23B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 311-409) antibodyRAD23B 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H7 unconjugated
anti-RAD23 Homolog B (RAD23B) antibodyRAD23B 适用: 人, 小鼠 WB, IHC, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibodyRAD23B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 164-409) antibodyRAD23B 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (Center) antibodyRAD23B 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 24-120) antibodyRAD23B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (N-Term) antibodyRAD23B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 1-250) antibodyRAD23B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- phosphate-buffered solution, pH 7.2, 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Upon receipt, store undiluted between 2°C and 8°C.
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- RAD23B (RAD23 Homolog B (RAD23B))
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别名
- Rad23B
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背景
- Yeast Rad23, originally identified as a DNA repair protein, has been proposed to participate in other cellular functions, i.e., the proteasome-degradation pathway, the process of spindle pole body duplication, and as a component of the anaphase checkpoint. Two human homologs of yeast Rad23 (Rad23A and Rad23B) exhibit high sequence homology with yeast Rad23 and also have been shown to be involved in DNA repair and proteasome-dependent degradation. Rad23B is involved in global genome nucleotide excision repair (GG-NER) by acting as a component of the XPC complex. The XPC complex recognizes a wide spectrum of damaged DNA, characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles, and single-stranded overhangs. The Rad23 family provides an essential connection between the 26S proteasome and ubiquitinated proteins. It can bind simultaneously to the 26S proteasome and to polyubiquitinated substrates to deliver ubiquitinated proteins to the proteasome. It may play a role in endoplasmatic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and by delivering deglycosylated proteins to the proteasome. The interactions of Rad23B, Atx3, and valosin-containing protein (VCP) are dynamic and modulated by proteotoxic stresses. Recent studies also show that Rad23B is a candidate cancer biomarker identified in a genome-wide loss-of-function screen, which influences sensitivity to HDAC inhibitors.
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途径
- DNA Damage Repair
抗原
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