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RANKL 抗体

TNFSF11 适用: 人 IHC, FACS 宿主: 小鼠 Monoclonal MIH24 unconjugated
产品编号 ABIN2664446
发货至: 中国
  • 抗原 See all RANKL (TNFSF11) 抗体
    RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This RANKL antibody is un-conjugated
    应用范围
    • 161
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    Immunohistochemistry (IHC), Flow Cytometry (FACS)
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    MIH24
    亚型
    IgG2b kappa
    Top Product
    Discover our top product TNFSF11 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
    别名
    CD254 (TNFSF11 产品)
    背景
    Human CD254, also known as RANKL, TRANCE, and OPGL, is a type II transmembrane protein in the TNF superfamily that has two forms: a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. CD254 is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of the interactions between T cells and dendritic cells. It plays an important role in osteoclast differentiation and bone resorption. CD254 activates JNK and NF-κB and induces the expression of IL-1, IL-6, IL-12, and IL-15 in dendritic cells.
    途径
    NF-kappaB Signaling
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