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SIGLEC8 抗体 (APC)

SIGLEC8 适用: 人 FACS, ICFC 宿主: 小鼠 Monoclonal 7C9 APC
产品编号 ABIN2658389
发货至: 中国
  • 抗原 See all SIGLEC8 抗体
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    适用
    • 42
    • 6
    • 2
    宿主
    • 32
    • 9
    • 1
    小鼠
    克隆类型
    • 34
    • 8
    单克隆
    标记
    • 23
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIGLEC8 antibody is conjugated to APC
    应用范围
    • 32
    • 20
    • 19
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
    纯化方法
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    克隆位点
    7C9
    亚型
    IgG1 kappa
    Top Product
    Discover our top product SIGLEC8 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect from prolonged exposure to light. Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    别名
    Siglec-8 (SIGLEC8 产品)
    别名
    SAF2 antibody, SIGLEC-8 antibody, SIGLEC8L antibody, SIGLEC8 antibody, sialic acid binding Ig like lectin 8 antibody, sialic acid-binding Ig-like lectin 8 antibody, SIGLEC8 antibody, LOC506364 antibody
    背景
    Siglec-8 is a lectin specific for 6'-sulfo-sLex and a member of the Ig-superfamily. It is expressed almost exclusively in eosinophils, however, basophils and mast cells can express it to a lower degree. Siglec-8 is a 54 kD transmembranal protein, the extracellular domain has one V-set Ig-like domain and two C2-set domains. The cytoplasmic domain has two immunoreceptor tyrosine-based inhibitor motifs (ITIM) that recruit SH2-family phosphatases after tyrosine phosphorylation. There are reports that siglec-8 inhibits the release of histamine and prostaglandin D2 mediated by the IgEFcR. This molelcule is also involved in the induction of apoptosis.
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