APC 抗体
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北京 101111
Quick Overview for APC 抗体 (ABIN265313)
抗原
See all APC 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of APC / DP2.5 protein (region surrounding Gln2829).
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Adenomatous Polyposis Coli (APC) (AA 2636-2845) antibody
APC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2544-2843) antibodyAPC 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2634-2842) antibodyAPC 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (pSer2054) antibodyAPC 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (C-Term) antibodyAPC 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2744-2843) antibodyAPC 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2751-2843) antibodyAPC 适用: 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (C-Term) antibodyAPC 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) antibodyAPC 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) antibodyAPC 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 5F2 unconjugated Recombinant Antibody
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应用备注
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ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- APC (Adenomatous Polyposis Coli (APC))
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别名
- APC / DP2.5
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背景
- Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellular processes. APC is a tumor suppressor, regulates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling. APC regulates ß-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.Synonyms: Adenomatous polyposis coli protein, Deleted in polyposis 2.5
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分子量
- approx. 310 kDa
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基因ID
- 324
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NCBI登录号
- NP_000029
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UniProt
- P25054
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途径
- WNT signaling, Stem Cell Maintenance, Cell-Cell Junction Organization
抗原
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