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BNIP3L/NIX 抗体 (AA 77-92)

Cited in 5+ publications. The 兔 多克隆 anti-BNIP3L/NIX antibody (ABIN264993) specifically detects BNIP3L/NIX in WB. The antibody is reactive with 人 samples.
产品编号 ABIN264993
发货至: 中国
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Quick Overview for BNIP3L/NIX 抗体 (AA 77-92) (ABIN264993)

抗原

See all BNIP3L/NIX (BNIP3L) 抗体
BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

适用

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宿主

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克隆类型

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多克隆

标记

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This BNIP3L/NIX antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    AA 77-92

    特异性

    This antibody recognizes Bnip3L (IN) (nix).

    纯化方法

    Purified

    免疫原

    Synthetic peptide corresponding to amino acids 77 to 92 of the human Bnip3L protein. Immunogen sequence is identical in the mouse protein.

    亚型

    IgG
  • 应用备注

    Western Blot: 0.5 to 1 μg/mL. Detects a 40 kDa band in K562 cell lysate which representsthe monomer of Bnip3L.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % Sodium Azide as a preservative

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    DO NOT FREEZE!

    储存条件

    4 °C

    储存方法

    The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8 °C.
  • Zhang, Randall, Loyd, Dorsey, Kundu, Cleveland, Ney: "Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation." in: Blood, Vol. 114, Issue 1, pp. 157-64, (2009) (PubMed).

    Qiu, Jiang, Xiang: "A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 13, pp. 3392-403, (2008) (PubMed).

    Marusyk, Wheeler, Mathews, DeGregori: "p53 mediates senescence-like arrest induced by chronic replicational stress." in: Molecular and cellular biology, Vol. 27, Issue 15, pp. 5336-51, (2007) (PubMed).

    Aerbajinai, Giattina, Lee, Raffeld, Miller: "The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation." in: Blood, Vol. 102, Issue 2, pp. 712-7, (2003) (PubMed).

    Clase, Lyman, del Rio, Randall, Calton, Enquist, Banfield: "The pseudorabies virus Us2 protein, a virion tegument component, is prenylated in infected cells." in: Journal of virology, Vol. 77, Issue 22, pp. 12285-98, (2003) (PubMed).

  • 抗原

    BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

    别名

    BNIP3L / BNIP3A

    背景

    Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3a, and Nix (for Nip3-like protein X) (1-3). Bnip3L/Bnip3a/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis (2,3). Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues (1,2). Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.Synonyms: Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, BNIP3H, NIP3-like protein X, NIX

    基因ID

    665

    NCBI登录号

    NP_004322

    UniProt

    O60238

    途径

    Autophagy
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