Fibrinogen 抗体
(2 references)Quick Overview for Fibrinogen 抗体 (ABIN264639)
抗原
See all Fibrinogen 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应 （详细）
- Species reactivity (tested):Mouse.
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纯化方法
- Protein A Chromatography.
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免疫原
- Native Mouse Fibrinogen.
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anti-Fibrinogen antibody
适用: 人, 大鼠 ELISA, IF (p), IHC (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Fibrinogen antibody适用: 人 IF (p), IHC (p) 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-Fibrinogen antibody适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C7 unconjugated
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应用备注
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ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 17.0 mg/mL (OD280nm, E0.1% = 1.36)
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缓冲液
- 0.05 M Sodium Phosphate, pH 6.6 containing 0.5 M Sodium Chloride and 1 mM EDTA, None
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody at -20 °C to -70 °C.
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: "Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13." in: Scientific reports, Vol. 6, pp. 25971, (2016) (PubMed).
: "Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation." in: Blood, Vol. 120, Issue 19, pp. 4082-92, (2012) (PubMed).
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: "Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13." in: Scientific reports, Vol. 6, pp. 25971, (2016) (PubMed).
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- Fibrinogen
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背景
- Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/mL. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.Synonyms: FGA, FGB, FGG
抗原
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