Cyclin E1 抗体
Quick Overview for Cyclin E1 抗体 (ABIN264331)
抗原
See all Cyclin E1 (CCNE1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
- Synonyms: Cyclin-E1, CCNE1, CCNE
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纯化方法
- Purified
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免疫原
- Recombinant full-length human cyclin E protein.
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亚型
- IgG2a
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anti-Cyclin E1 (CCNE1) (AA 10-176) antibody
CCNE1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal CCNE1-2460 unconjugated
anti-Cyclin E1 (CCNE1) (AA 1-100) antibodyCCNE1 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1C8D4 unconjugated
anti-Cyclin E1 (CCNE1) (AA 307-410) antibodyCCNE1 适用: 人, 小鼠 ELISA, FACS 宿主: 小鼠 Monoclonal 5F8C5 unconjugated
anti-Cyclin E1 (CCNE1) (AA 375-411) antibodyCCNE1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin E1 (CCNE1) (AA 1-410) antibodyCCNE1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin E1 (CCNE1) (AA 307-410) antibodyCCNE1 适用: 人, 小鼠 宿主: 小鼠 Monoclonal unconjugated
anti-Cyclin E1 (CCNE1) (Thr395) antibodyCCNE1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin E1 (CCNE1) antibodyCCNE1 适用: 人 IHC, ELISA, IF 宿主: 兔 Monoclonal 3A5 unconjugated Recombinant Antibody
anti-Cyclin E1 (CCNE1) (AA 1-410) antibodyCCNE1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cyclin E1 (CCNE1) (C-Term) antibodyCCNE1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: A 50 kDa band corresponding to human cyclin E protein is detected. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.08 % Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
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Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch. -
有效期
- 12 months
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- Cyclin E1 (CCNE1)
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别名
- Cyclin E1
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背景
- Human cyclin E was originally identified by complementation of a triple cln deletion in Saccharomyces cerevisiae. Following the identification of human cyclin E protein, researchers found that breast cancers and some other solid tumors exhibited both quantitative and qualitative alterations in cyclin E protein production. In particular, the alterations in cyclin E expression in breast cancer correlated with increasing stage and grade of the tumor. These results suggested that cyclin E might be useful as a prognostic marker. More recently, Geng et al generated a mouse strain in which the coding sequences for cyclin D1 was deleted and replaced with those of human cyclin E. Replacement of cyclin D1 with cyclin E rescued all phenotypic manifestations seen in the cyclin D1 deficient mice and restored normal development to cyclin D1-dependent tissues. Based on the results of these studies, it appears that cyclin E is the major downstream target of cyclin D1. In addition to functioning downstream of cyclin D1, recent studies with Xenopus egg extracts demonstrated that cyclin E localizes to the centrosome. In these studies CDK2-cyclin E activity was shown to be required for centrosome duplication during S phase. Taken together, these data suggest a mechanism that coordinates centrosome reproduction with cycles of DNA synthesis and mitosis.Synonyms: CCNE, CCNE1, Cyclin-E1
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基因ID
- 898
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UniProt
- P24864
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途径
- Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
抗原
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