PKC alpha 抗体 (pTyr658)
Quick Overview for PKC alpha 抗体 (pTyr658) (ABIN2568432)
抗原
See all PKC alpha (PKCa) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr658
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特异性
- The antibody detects endogenous levels of PKC alpha only when phosphorylated at tyrosine 658.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- PKC alpha (phospho Tyr658) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 658 (F-S-Y (p)-V-N) derived from Human PKC alpha.
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亚型
- IgG
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anti-Protein Kinase C, alpha (PKCa) (AA 563-672) antibody
PKCa 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 2F11 unconjugated
anti-Protein Kinase C, alpha (PKCa) antibodyPKCa 适用: 人, 小鼠, 大鼠 WB, IHC, IP, IF, FACS, ICC 宿主: 兔 Monoclonal unconjugated
anti-Protein Kinase C, alpha (PKCa) (AA 299-329) antibodyPKCa 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, alpha (PKCa) (pThr638) antibodyPKCa 适用: 人, 小鼠 WB, IHC (p), FACS, IF (cc) 宿主: 兔 Monoclonal 4B3 unconjugated
anti-Protein Kinase C, alpha (PKCa) (pThr638) antibodyPKCa 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, alpha (PKCa) (AA 299-329), (C-Term) antibodyPKCa 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB01012 unconjugated
anti-Protein Kinase C, alpha (PKCa) (C-Term) antibodyPKCa 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, alpha (PKCa) antibodyPKCa 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Protein Kinase C, alpha (PKCa) (N-Term) antibodyPKCa 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, alpha (PKCa) (AA 75-103), (N-Term) antibodyPKCa 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB20769 unconjugated
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应用备注
- Western Blot: 1:500~1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- PKC alpha (PKCa) (Protein Kinase C, alpha (PKCa))
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别名
- PKC alpha
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背景
- Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells.
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分子量
- 80 kDa
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基因ID
- 5578
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NCBI登录号
- NP_002728
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UniProt
- P17252
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途径
- WNT signaling, TCR Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling
抗原
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