CD3 epsilon 抗体 (PE)
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- 抗原 See all CD3 epsilon (CD3E) 抗体
- CD3 epsilon (CD3E)
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适用
- 小鼠
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宿主
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仓鼠
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克隆类型
- 单克隆
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标记
- This CD3 epsilon antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex.
- 纯化方法
- The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- 克隆位点
- 145-2C11
- 亚型
- IgG
- Top Product
- Discover our top product CD3E Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.2 mg/mL
- 缓冲液
- Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.
- 储存条件
- 4 °C
- 储存方法
- The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
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- 抗原
- CD3 epsilon (CD3E)
- 别名
- CD3e (CD3E 产品)
- 背景
- The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex. Together with the γ and δ subunits of CD3, the ε subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the ε chain enhances the antigen recognition.The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes. The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.
- 基因ID
- 12501
- UniProt
- P22646
- 途径
- TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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