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CTLA4 抗体

CTLA4 适用: 小鼠 FACS 宿主: 仓鼠 Monoclonal UC10-4F10-11 unconjugated
产品编号 ABIN2567246
发货至: 中国
  • 抗原 See all CTLA4 抗体
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    适用
    • 109
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    小鼠
    宿主
    • 70
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    仓鼠
    克隆类型
    • 86
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    单克隆
    标记
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    This CTLA4 antibody is un-conjugated
    应用范围
    • 86
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    Flow Cytometry (FACS)
    特异性
    The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152.
    纯化方法
    The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.
    克隆位点
    UC10-4F10-11
    亚型
    IgG1 kappa
    Top Product
    Discover our top product CTLA4 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    2.0 mg/mL
    缓冲液
    Phosphate-buffered aqueous solution, ph7.2.
    储存条件
    4 °C
    储存方法
    The product should be stored undiluted at 4°C. Do not freeze.
  • 抗原
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    别名
    CD152 (CTLA4 产品)
    背景
    The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
    基因ID
    12477
    UniProt
    P09793
    途径
    Cancer Immune Checkpoints
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