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CTLA4 抗体

CTLA4 适用: 人 FACS 宿主: 小鼠 Monoclonal BNI3 unconjugated
产品编号 ABIN2567240
发货至: 中国
  • 抗原 See all CTLA4 抗体
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This CTLA4 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS)
    特异性
    The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4).
    纯化方法
    The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.
    克隆位点
    BNI3
    亚型
    IgG2a kappa
    Top Product
    Discover our top product CTLA4 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    2.0 mg/mL
    缓冲液
    Phosphate-buffered aqueous solution, ph7.2.
    储存条件
    4 °C
    储存方法
    The product should be stored undiluted at 4°C. Do not freeze.
  • 抗原
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    别名
    CD152 (CTLA4 产品)
    背景
    The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
    基因ID
    1493
    UniProt
    P16410
    途径
    Cancer Immune Checkpoints
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