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CTLA4 抗体

CTLA4 适用: 人 FACS, IHC, IP, Func 宿主: 小鼠 Monoclonal BNI3 unconjugated
产品编号 ABIN2567238
发货至: 中国
  • 抗原 See all CTLA4 抗体
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This CTLA4 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Functional Studies (Func)
    特异性
    The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4).
    纯化方法
    The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
    克隆位点
    BNI3
    亚型
    IgG2a kappa
    Top Product
    Discover our top product CTLA4 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.
    储存条件
    4 °C
    储存方法
    The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
  • 抗原
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    别名
    CD152 (CTLA4 产品)
    背景
    The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
    基因ID
    1493
    UniProt
    P16410
    途径
    Cancer Immune Checkpoints
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