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- 抗原 See all JAG1 抗体
- JAG1 (Jagged 1 (JAG1))
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抗原表位
- AA 110-125
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This JAG1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 纯化方法
- Protein A Column
- 免疫原
- JAG1 antibody was raised against a synthetic peptide corresponding to aa 110 - 125 of JAG1 (Human).
- 亚型
- IgG
- Top Product
- Discover our top product JAG1 Primary Antibody
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anti-Jagged 1 (JAG1) (Internal Region) antibody
JAG1 适用: 人, 小鼠 WB, ELISA, IHC, FM 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (AA 47-212) antibodyJAG1 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 6A9B2 unconjugated
anti-Jagged 1 (JAG1) (AA 836-1047) antibodyJAG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (AA 809-1046) antibodyJAG1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) antibodyJAG1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal J1G53-3 unconjugated
anti-Jagged 1 (JAG1) (AA 470-834) antibodyJAG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (AA 33-250) antibodyJAG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (AA 826-1084) antibodyJAG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (N-Term) antibodyJAG1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Jagged 1 (JAG1) (C-Term) antibodyVerified JAG1 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- JAG1 antibody can be used in Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunocytochemistry.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS, pH 7.2, 0.01 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- As with all antibodies avoid freeze/thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store JAG1 antibody at 4 °C or -20 °C.
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- 抗原
- JAG1 (Jagged 1 (JAG1))
- 别名
- JAG1 (JAG1 产品)
- 别名
- AGS antibody, AHD antibody, AWS antibody, CD339 antibody, HJ1 antibody, JAGL1 antibody, ABE2 antibody, Gsfabe2 antibody, Htu antibody, Ozz antibody, Ser-1 antibody, JAG1 antibody, jag3 antibody, cb243 antibody, jag1 antibody, sb:cb243 antibody, serrateC antibody, jagged1 antibody, serrate antibody, serrate-1 antibody, x-serrate-1 antibody, jagged 1 antibody, jagged 1b antibody, jagged 1a antibody, jagged 1 L homeolog antibody, JAG1 antibody, Jag1 antibody, jag1 antibody, jag1b antibody, jag1a antibody, jag1.L antibody
- 背景
- Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notch and related receptors. JAG1 functions in an embryologically important signaling pathway and has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation of cd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravating factor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 induces monocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro. Either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the Alagille syndrome. A BLAST analysis was used to suggest crossreactivity with Jagged-1 protein from human, chimpanzee, rat and mouse based on 100 % homology with the immunizing sequence. Partial reactivity is expected against canine (81 %) and Xenopus laevis (85 %) based on partial sequence homologies as indicated. The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
- 基因ID
- 182
- UniProt
- P78504
- 途径
- Notch Signaling, Stem Cell Maintenance
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