Recognizes human PTH/PTHrP receptor, Mr 80kD, and the receptor dimer, Mr 160kD. A faint nonspecific band at 110kD is also detected. This antibody does not detect the PTH2 receptor.
纯化方法
Protein G Column
免疫原
PTHR1 monoclonal antibody was raised against a synthetic peptide corresponding to aa 146 - 169 of PTHR1 (Human).
PTHR1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 15 μg/mL.
限制
仅限研究用
状态
Liquid
缓冲液
PBS, pH 7.6, 0.07 % sodium azide, 30 % glycerol
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
As with all antibodies avoid freeze/thaw cycles.
储存条件
4 °C/-20 °C
储存方法
Product should be stored long term (months) at -20 °C and short term (weeks) at 4 °C.
抗原
PTH1R
(Parathyroid Hormone 1 Receptor (PTH1R))
别名
PTHR1
背景
PTHR1, a Parathyroid Hormone Receptor, mediates PTH-dependent regulation of mineral-ion homeostasis. It also mediates the paracrine action of PTHRP in endochondral bone formation. Mutations in this receptor are responsible for disorders of calcium and bone metabolism such as chondrodysplasia, hypercalcemia, and chronic renal failure. Three promoters, P1, P2, and P3, regulate the expression of PTHR.