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NOTCH2 抗体 (N-Term)

Name: NOTCH2 抗体 (N-Term)
SKU: ABIN2470258
Availability: OutOfStock

This anti-NOTCH2 antibody is a 兔多克隆 antibody detecting NOTCH2 in WB, ELISA, IHC 和 IF. Suitable for 人, 犬和 Chimpanzee.

Immunohistochemistry (IHC) image for anti-Notch 2 (NOTCH2) (N-Term) antibody (ABIN2470258) (NOTCH2 抗体 (N-Term))

IHC

1 image

产品编号 ABIN2470258

发货至: 中国

Quick Overview for NOTCH2 抗体 (N-Term) (ABIN2470258)

抗原

See all NOTCH2 抗体

NOTCH2 (Notch 2 (NOTCH2))

适用

人, 犬, Chimpanzee

宿主

兔

克隆类型

多克隆

标记

This NOTCH2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Discover our top product NOTCH2 Primary Antibody

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N-Term

纯化方法

Sterile Filtration

免疫原

NOTCH2 antibody was raised against amino acid residues 2396 - 2409 of NOTCH2. A residue of cysteine was added to the amino terminal end to facilitate coupling (Human).
anti-Notch 2 (NOTCH2) antibody
NOTCH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) (Asp1733), (cleaved) antibody
NOTCH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) (C-Term) antibody
NOTCH2 适用: 人, 小鼠 WB, ChIP-seq 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) (AA 1501-1700) antibody
NOTCH2 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) (Cleaved-Asp1733) antibody
NOTCH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) (AA 59-250) antibody
NOTCH2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) (AA 2251-2466) antibody
NOTCH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) (AA 2242-2471) antibody
NOTCH2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) (Cleaved-Ala1734) antibody
NOTCH2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Notch 2 (NOTCH2) antibody
NOTCH2 适用: 人, 小鼠 FACS 宿主: 大鼠 Monoclonal 16F11 unconjugated

应用备注

NOTCH2 antibody can be used in Western Blot starting at 0.5 - 4 μg/mL, and immunohistochemistry starting at 5 μg/mL.

限制

仅限研究用
状态

Liquid

缓冲液

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.1 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

As with all antibodies avoid freeze/thaw cycles.

储存条件

4 °C/-20 °C

储存方法

Store NOTCH2 antibody at 4 °C or -20 °C.
抗原

NOTCH2 (Notch 2 (NOTCH2))

别名

NOTCH2

背景

Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane. Notch functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

基因ID

4853

UniProt

Q04721

途径

Notch Signaling, Stem Cell Maintenance