MST1R 抗体 (Internal Region)
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Quick Overview for MST1R 抗体 (Internal Region) (ABIN2469460)
抗原
See all MST1R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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纯化方法
- Immunoaffinity Chromatography
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免疫原
- MST1R antibody was raised against a peptide located near the internal domain of MST1R (Human).
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应用备注
- MST1R antibody can be used in immunohistochemistry starting at 20 μg/mL, and immunofluorescence.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, 0.1 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- As with all antibodies avoid freeze/thaw cycles.
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储存条件
- 4 °C/-80 °C
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储存方法
- MST1R antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.
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- MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))
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别名
- MST1R
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背景
- MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers.
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基因ID
- 4486
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UniProt
- Q04912
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途径
- RTK signaling
抗原
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