C3 抗体
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北京 101111
Quick Overview for C3 抗体 (ABIN2467785)
抗原
See all C3 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antigen affinity-purified
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免疫原
- plasma protein
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应用备注
- C3 antibody can be used for the detection of C3 by Western blot, ELISA, may also work for IHC and ICC.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate-Buffered Saline. No preservatives added.
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储存液
- Without preservative
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注意事项
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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储存条件
- 4 °C/-20 °C
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储存方法
- C3 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.
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- C3 (Complement Component 3 (C3))
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别名
- Complement Component C3
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背景
- Human complement component C3. Complement C3 contains two chains linked by a disulfide bond. Its activation by a C3 convertase releases the C3a anaphylatoxin from the amino end of the alpha chain and generates C3b, which associates with the Bb fragment of complement factor B to form the alternative-complement-pathway C3/C5 convertase.C3a anaphylatoxin is a vasoactive peptide and a mediator of inflammation. C3b, with its highly reactive thiol group, binds to the surface of foreign particles and facilitates phagocytosis. It binds to complement C5 and renders it susceptible to proteolysis by the classical-complement-pathway C3/C5 convertase. The activity of C3b is regulated by proteolytic cleavage involving factors H and I. Its degradation products can also be biologically active.
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分子量
- 187.2 kDa (calculated)
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基因ID
- 718
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NCBI登录号
- NP_000055
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UniProt
- P01024
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途径
- Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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