Topoisomerase II alpha 抗体
Quick Overview for Topoisomerase II alpha 抗体 (ABIN2463687)
抗原
See all Topoisomerase II alpha (TOP2A) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Antibody is purified by protein A chromatography method.
-
免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TOP2A.
-
-
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) antibody
TOP2A 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1435-1531) antibodyTOP2A 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E2 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1352-1493) antibodyTOP2A 适用: 人, 小鼠 WB, IHC, IF, StM 宿主: 小鼠 Monoclonal TOP2A-1361 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1100-1530) antibodyTOP2A 适用: 人, 大鼠 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 6C12G12 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1100-1530) antibodyTOP2A 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6D4B2 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (Internal Region) antibodyTOP2A 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (N-Term) antibodyTOP2A 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (C-Term) antibodyTOP2A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1167-1196), (C-Term) antibodyTOP2A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB24346 unconjugated
anti-Topoisomerase (DNA) II alpha 170kDa (TOP2A) (Thr1343) antibodyTOP2A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- TOP2A antibody can be used for detection of TOP2A by ELISA at 1:62500. TOP2A antibody can be used for detection of TOP2A by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
-
注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store TOP2A antibody at -20 °C.
-
-
- Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
-
别名
- TOP2A
-
背景
- TOP2A is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
-
分子量
- 174 kDa
-
基因ID
- 7153
-
NCBI登录号
- NP_001058
-
UniProt
- P11388
-
途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
抗原
-
