ERBB3 抗体
-
- 抗原 See all ERBB3 抗体
- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This ERBB3 antibody is un-conjugated
-
应用范围
- Immunohistochemistry (IHC), Flow Cytometry (FACS)
- 纯化方法
- Protein G
- 免疫原
- genetic immunisation with cDNA encoding human ErbB-3
- 克隆位点
- DY-7G2
- 亚型
- IgG1
- Top Product
- Discover our top product ERBB3 Primary Antibody
-
-
- 应用备注
-
Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration. - 说明
-
Synonyms: Her3
- 限制
- 仅限研究用
-
- 缓冲液
- PBS, pH 7.2
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C
- 储存方法
- short term: 2 °C - 8 °C, long term: -20 °C
-
- 抗原
- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
- 别名
- ErbB3 (ERBB3 产品)
- 背景
- ErbB-3 belongs to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. The 148-kDa trans-membrane polypeptide ErbB-3 has a neuregulin binding domain but not an active kinase domain. Heterodimerisation with EGF receptor family members which possess kinase activity leads to the activation of pathways which indicate cell proliferation or differentiation (1). Over-expression of ErbB-3 has been reported in numerous cancers, including prostate, bladder and breast tumours.
- UniProt
- P21860
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
-