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CD59 抗体

This anti-CD59 antibody is a 小鼠 单克隆 antibody detecting CD59 in WB, FACS, IP 和 Inhibition. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2191998
发货至: 中国

Quick Overview for CD59 抗体 (ABIN2191998)

抗原

See all CD59 抗体
CD59

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD59 antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Antibody (Inhibition)

克隆位点

MEM-43
  • 过滤

    0.2 μm filtered

    内毒素水平

    Low endotoxin level
  • 应用备注

    For flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For neutralization of biological activity dilutions have to be made according to the amounts endotoxin to be inactivated.

    限制

    仅限研究用
  • 缓冲液

    PBS and 0.1 % bovine serum albumin with low endotoxin level.

    储存条件

    4 °C

    储存方法

    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

    有效期

    12 months
  • Yamamoto, Nakane, Doi, Osaki: "Lipopolysaccharide signal transduction in oral keratinocytes--involvement of CD59 but not CD14." in: Cellular signalling, Vol. 15, Issue 9, pp. 861-9, (2003) (PubMed).

  • 抗原

    CD59

    别名

    CD59

    背景

    The antibody is the prototypic antibody for the CD59 determinant, a PI-linked glycoprotein of 18-25 kDa, which is broadly expressed on most types of cells. The antigen is the major complement-protecting molecule of human cells. It is expressed on all leukocytes, erythrocytes and most other cell types. Binding of this antibody inhibits the complement-protecting activity of CD59. CD59 is one of the complement regulatory membrane proteins that is missing in Paroxysmal Nocturnal Haemoglobinuria (PNH). Anti CD59 reagents may be useful in the differential diagnosis of PNH type II and PNH type I. Recently a role for CD59 in LPS signal transduction has been reported in keratinocytes. The antibody reacts with well defined epitope (W40, R-53) on CD59 Molecule.

    途径

    Complement System
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