C1S 抗体
(1 reference)Quick Overview for C1S 抗体 (ABIN2191986)
抗原
See all C1S 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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anti-Complement Component 1, S Subcomponent (C1S) (AA 1-688) antibody
C1S 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (C-Term) antibodyC1S 适用: 人 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 IHC, ELISA, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (AA 1-688) antibodyC1S 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2F5 unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (AA 438-685) antibodyC1S 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (Cleaved-Arg437) antibodyC1S 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (AA 519-688) antibodyC1S 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For inhibition of C4 activation by C1s dilutions have to be made according to the amounts C1s to be inactivated.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.1 % bovine serum albumin.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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: "Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 8, pp. 2743-50, (1989) (PubMed).
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: "Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 8, pp. 2743-50, (1989) (PubMed).
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- C1S (Complement Component 1, S Subcomponent (C1S))
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别名
- c1s
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背景
- Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M81 blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.
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途径
- Complement System
抗原
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