TLR9 抗体
(2 references)-
- 抗原 See all TLR9 抗体
- TLR9 (Toll-Like Receptor 9 (TLR9))
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TLR9 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA), Detection (D)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 5G5
- Top Product
- Discover our top product TLR9 Primary Antibody
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anti-Toll-Like Receptor 9 (TLR9) (AA 868-1016) antibody
TLR9 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1B12H2 unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 28-362) antibodyTLR9 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 268-300) antibodyTLR9 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, FACS, IHC (p), ICC, IP, IF 宿主: 小鼠 Monoclonal 26C593-2 unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 350-450) antibodyTLR9 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 26-193) antibodyTLR9 适用: 人 WB, IHC, ELISA, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 5B10E8 unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 951-1032) antibodyTLR9 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 9 (TLR9) (AA 99-215) antibodyTLR9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E8 unconjugated
anti-Toll-Like Receptor 9 (TLR9) antibody (Biotin)TLR9 适用: 人 WB, FACS, IHC (p), IF 宿主: 小鼠 Monoclonal 5G5 Biotin
anti-Toll-Like Receptor 9 (TLR9) (N-Term) antibodyTLR9 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 9 (TLR9) antibodyTLR9 适用: 人 WB, FACS, IHC (p), IF 宿主: 小鼠 Monoclonal 5G5 unconjugated
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- 应用备注
- For immunohistology, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry." in: Veterinary immunology and immunopathology, Vol. 124, Issue 1-2, pp. 184-91, (2008) (PubMed).
: "Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner." in: European journal of immunology, Vol. 34, Issue 9, pp. 2541-50, (2004) (PubMed).
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: "Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry." in: Veterinary immunology and immunopathology, Vol. 124, Issue 1-2, pp. 184-91, (2008) (PubMed).
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- 抗原
- TLR9 (Toll-Like Receptor 9 (TLR9))
- 别名
- Toll-Like Receptor 9 (TLR9 产品)
- 别名
- CD289 antibody, toll like receptor 9 antibody, toll-like receptor 9 antibody, TLR9 antibody, Tlr9 antibody
- 背景
- The monoclonal antibody 5G5 reacts with the Toll-like receptor 9 (TLR9, CD289). TLRs are highly conserved throughout evolution and have been implicated in the innate defence to many pathogens. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. In mammals, TLRs identified as type I transmembrane signalling receptors with pattern recognition capabilities, have been implicated in the innate host defence to pathogens. As investigated so far all functional characterized TLR signal via the TLR/IL-1 receptor (IL-1R) pathway where recruitment of MyD88 seems to be essential. In contrast to cell-wall components, bacterial DNA is probably invisible for immune cells until DNA is liberated during processes taking place in the endosomal/lysosomal compartment where intracellular TLR9 recruits MyD88 to initiate signal transduction. Unmethylated CpG-dinucleotide-containing sequences are found much more frequently in bacterial genomes than in vertebrates genomes, whereas the frequency of CpG dinucleotides are suppressed and usually methylated. The regions adjacent to the CpG dinucleotides also affect the immunostimulatory activity. The optimal sequence differs significantly between mammalian species. Methylated CpG dinucleotides lack immunostimulatory activities. Cellular activation in response to bacterial DNA and synthetic dinucleotides containing unmethylated CpG- dinucleotides is mediated by TLR9. The monoclonal antibody 5G5 reacts with RAW macrophages and TLR9 transfected HEK293 cells, and it is cross reactive with canine TLR9.
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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