电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

IRAK4 抗体 (pThr345)

IRAK4 适用: 人, 小鼠 WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2177052
发货至: 中国
  • 抗原 See all IRAK4 抗体
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    抗原表位
    • 35
    • 16
    • 15
    • 11
    • 8
    • 8
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr345
    适用
    • 112
    • 65
    • 27
    • 15
    • 14
    • 12
    • 3
    • 3
    • 2
    • 2
    • 1
    人, 小鼠
    宿主
    • 107
    • 10
    • 1
    克隆类型
    • 107
    • 11
    多克隆
    标记
    • 50
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRAK4 antibody is un-conjugated
    应用范围
    • 109
    • 50
    • 36
    • 25
    • 17
    • 14
    • 13
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    人, 小鼠
    预测反应
    Rat,Dog,Cow,Sheep,Pig,Rabbit,Guinea Pig
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated Synthesised phosphopeptide derived from human IRAK4 around the phosphorylation site of Thr345
    亚型
    IgG
    Top Product
    Discover our top product IRAK4 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    别名
    IRAK4 (IRAK4 产品)
    别名
    zgc:55553 antibody, IRAK4 antibody, ipd1 antibody, irak-4 antibody, ny-ran-64 antibody, ny-ren-64 antibody, ren64 antibody, irak4 antibody, IPD1 antibody, IRAK-4 antibody, NY-REN-64 antibody, REN64 antibody, 8430405M07Rik antibody, 9330209D03Rik antibody, interleukin 1 receptor associated kinase 4 antibody, interleukin-1 receptor-associated kinase 4 antibody, IRAK4 antibody, irak4 antibody, Irak4 antibody
    背景

    Synonyms: IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64, IRAK4

    Background: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

    基因ID
    51135
    UniProt
    Q9NWZ3
    途径
    NF-kappaB Signaling, TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
You are here:
客服