RAD23B 抗体 (AA 24-120)
Quick Overview for RAD23B 抗体 (AA 24-120) (ABIN2175752)
抗原
See all RAD23B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 24-120
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Pig,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human hHR23b
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亚型
- IgG
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anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibody
RAD23B 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 50-150) antibodyRAD23B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 311-409) antibodyRAD23B 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H7 unconjugated
anti-RAD23 Homolog B (RAD23B) antibodyRAD23B 适用: 人, 小鼠 WB, IHC, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibodyRAD23B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 164-409) antibodyRAD23B 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (Center) antibodyRAD23B 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (N-Term) antibodyRAD23B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (AA 1-250) antibodyRAD23B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAD23 Homolog B (RAD23B) (N-Term) antibodyRAD23B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- RAD23B (RAD23 Homolog B (RAD23B))
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别名
- hHR23b
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背景
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Synonyms: P58, HR23B, HHR23B, UV excision repair protein RAD23 homolog B, XP-C repair-complementing complex 58 kDa protein, RAD23B
Background: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
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基因ID
- 5887
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UniProt
- P54727
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途径
- DNA Damage Repair
抗原
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