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RAD23B 抗体 (AA 24-120)

Name: RAD23B 抗体 (AA 24-120)
SKU: ABIN2175752
Availability: OutOfStock

This anti-RAD23B antibody is a 兔多克隆 antibody detecting RAD23B in WB, ELISA, IHC (p), ICC, IF (p), IF (cc) 和 IHC (fro). Suitable for 人, 小鼠和大鼠.

Lane 1: Raji lysates probed with Rabbit Anti-hHR23b Polyclonal Antibody, Unconjugated (ABIN2175752) at 1:300 overnight at 4 °C. (RAD23B 抗体 (AA 24-120))

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-hHR23b Polyclonal Antibody, Unconjugated (ABIN2175752) at 1:200 followed by conjugation to the secondary antibody and DAB staining (RAD23B 抗体 (AA 24-120))

IHC (p)

2 images

产品编号 ABIN2175752

发货至: 中国

Quick Overview for RAD23B 抗体 (AA 24-120) (ABIN2175752)

抗原

See all RAD23B 抗体

RAD23B (RAD23 Homolog B (RAD23B))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This RAD23B antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product RAD23B Primary Antibody

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AA 24-120

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Pig,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human hHR23b

亚型

IgG
anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibody
RAD23B 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (AA 50-150) antibody
RAD23B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (AA 311-409) antibody
RAD23B 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H7 unconjugated

anti-RAD23 Homolog B (RAD23B) antibody
RAD23B 适用: 人, 小鼠 WB, IHC, ICC 宿主: 小鼠 Monoclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibody
RAD23B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (AA 164-409) antibody
RAD23B 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (Center) antibody
RAD23B 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (N-Term) antibody
RAD23B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (AA 1-250) antibody
RAD23B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (N-Term) antibody
RAD23B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

RAD23B (RAD23 Homolog B (RAD23B))

别名

hHR23b

背景

Synonyms: P58, HR23B, HHR23B, UV excision repair protein RAD23 homolog B, XP-C repair-complementing complex 58 kDa protein, RAD23B
Background: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.

基因ID

5887

UniProt

P54727

途径

DNA Damage Repair