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CDK2 抗体 (AA 201-298)

Name: CDK2 抗体 (AA 201-298)
SKU: ABIN2172816
Availability: OutOfStock

This anti-CDK2 antibody is a 兔多克隆 antibody detecting CDK2 in WB, ELISA, FACS, ICC, IHC (p), IF (p), IF (cc) 和 IHC (fro). Suitable for 人和小鼠. This Primary Antibody has been cited in 2+ publications.

Mouse testis lysates probed with CDK2 Polyclonal Antibody, Unconjugated at 1:300 dilution and 4˚C overnight incubation. (CDK2 抗体 (AA 201-298))

1 image

(2 references)

产品编号 ABIN2172816

发货至: 中国

Quick Overview for CDK2 抗体 (AA 201-298) (ABIN2172816)

抗原

See all CDK2 抗体

CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This CDK2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

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AA 201-298

交叉反应

人, 小鼠

预测反应

Rat,Cow,Pig,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human CDK2

亚型

IgG
anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
CDK2 适用: 人, 小鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1A6 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 211-298) antibody
CDK2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2E8 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
CDK2 适用: 人, 猴 WB, FACS, IF 宿主: 小鼠 Monoclonal 4B4 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 197-295) antibody
CDK2 适用: 人, 小鼠 WB, IHC, ELISA, FACS, IF 宿主: 小鼠 Monoclonal 1A6 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 1-298) antibody
CDK2 适用: 人 WB, IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) antibody
CDK2 适用: 人, 猴 WB, FACS, IF 宿主: 小鼠 Monoclonal 1C4 unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 81-298) antibody
CDK2 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 94-198) antibody
CDK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (AA 93-211) antibody
CDK2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 2 (CDK2) (pThr160) antibody
CDK2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Wang, Yang, Liu, Huang, Wang, Chen, Chen: "RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway." in: Biochemical and biophysical research communications, Vol. 454, Issue 1, pp. 71-7, (2015) (PubMed).

He, Xiang, Zong, Yan, Yu, Liu, Zou, Yang: "CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro." in: Cancer cell international, Vol. 14, Issue 1, pp. 130, (2014) (PubMed).
抗原

CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

别名

CDK2

背景

Synonyms: CDKN2, p33(CDK2), Cyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDK2
Background: Serine/threonine-protein kinase involved in the control of the cell cycle, essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression, controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2, activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis, regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication.

基因ID

1017

UniProt

P24941

途径

PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA