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Retinoblastoma Protein (Rb) 抗体 (Cleavage Site)

This anti-Retinoblastoma Protein (Rb) antibody is a 小鼠 单克隆 antibody detecting Retinoblastoma Protein (Rb) in WB 和 IHC. Suitable for 人 和 小鼠.
产品编号 ABIN207915
发货至: 中国

Quick Overview for Retinoblastoma Protein (Rb) 抗体 (Cleavage Site) (ABIN207915)

抗原

See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体
Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

适用

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人, 小鼠

宿主

  • 124
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小鼠

克隆类型

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单克隆

标记

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This Retinoblastoma Protein (Rb) antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)

克隆位点

172C1094
  • 抗原表位

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    Cleavage Site

    特异性

    Recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).

    纯化方法

    Protein G purified

    免疫原

    A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.

    Type of Immunogen: Synthetic peptide

    亚型

    IgG1
  • 应用备注

    Approved: IHC, WB (2 μg/mL)

    Not recommended for: IHC-P

    说明

    Target Species of Antibody: Human

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    PBS, 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Short term: 4°C
    Long term: -70°C.
  • 抗原

    Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

    别名

    RB1 / Retinoblastoma / RB

    背景

    Name/Gene ID: RB1

    Synonyms: RB1, p105-Rb, Osteosarcoma, PRb, Retinoblastoma, Retinoblastoma 1, OSRC, RB, Pp110

    基因ID

    5925

    UniProt

    P06400

    途径

    Mitotic G1-G1/S Phases
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