Retinoblastoma Protein (Rb) 抗体 (Cleavage Site)
Quick Overview for Retinoblastoma Protein (Rb) 抗体 (Cleavage Site) (ABIN207915)
抗原
See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Cleavage Site
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特异性
- Recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
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纯化方法
- Protein G purified
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免疫原
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A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.
Type of Immunogen: Synthetic peptide -
亚型
- IgG1
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应用备注
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Approved: IHC, WB (2 μg/mL)
Not recommended for: IHC-P -
说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
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Short term: 4°C
Long term: -70°C.
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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别名
- RB1 / Retinoblastoma / RB
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背景
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Name/Gene ID: RB1
Synonyms: RB1, p105-Rb, Osteosarcoma, PRb, Retinoblastoma, Retinoblastoma 1, OSRC, RB, Pp110 -
基因ID
- 5925
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UniProt
- P06400
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途径
- Mitotic G1-G1/S Phases
抗原
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