ADAM10 抗体 (AA 732-748)
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Quick Overview for ADAM10 抗体 (AA 732-748) (ABIN1886898)
抗原
See all ADAM10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 732-748
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纯化方法
- Ion exchange chromatography purified
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免疫原
- Peptide corresponding to amino acids 732 to 748 of human ADAM10.This sequence is identical to those of bovine and rat origins and differs from that of mouse ADAM10 by one amino acid (2,4).
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))
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别名
- ADAM10
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背景
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Proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) contributes to a variety of inflammatory responses and programmed cell death.Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma.TNF-alpha, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor.ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-alpha, notch and its ligand delta.The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively.ADAM10 mRNA is expressed in a variety of human and bovine tissues.
Synonyms: KUZ -
NCBI登录号
- NP_001101
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途径
- Notch Signaling, EGFR Signaling Pathway
抗原
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