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ADAM10 抗体 (AA 732-748)

This anti-ADAM10 antibody is a 兔 多克隆 antibody detecting ADAM10 in WB, ELISA 和 ICC. Suitable for 人.
产品编号 ABIN1886898
发货至: 中国

Quick Overview for ADAM10 抗体 (AA 732-748) (ABIN1886898)

抗原

See all ADAM10 抗体
ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

适用

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宿主

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克隆类型

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多克隆

标记

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This ADAM10 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
  • 抗原表位

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    AA 732-748

    纯化方法

    Ion exchange chromatography purified

    免疫原

    Peptide corresponding to amino acids 732 to 748 of human ADAM10.This sequence is identical to those of bovine and rat origins and differs from that of mouse ADAM10 by one amino acid (2,4).
  • 限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

    注意事项

    Avoid freezing and thawing repeatly.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 4 °C for short term use.Store at -20 °C for long term preservation.
  • 抗原

    ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

    别名

    ADAM10

    背景

    Proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) contributes to a variety of inflammatory responses and programmed cell death.Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma.TNF-alpha, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor.ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-alpha, notch and its ligand delta.The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively.ADAM10 mRNA is expressed in a variety of human and bovine tissues.
    Synonyms: KUZ

    NCBI登录号

    NP_001101

    途径

    Notch Signaling, EGFR Signaling Pathway
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