CCR5 抗体 (AA 6-20)
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北京 101111
Quick Overview for CCR5 抗体 (AA 6-20) (ABIN1886891)
抗原
See all CCR5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 6-20
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纯化方法
- Purified by DEAE column
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免疫原
- Peptide corresponding to amino acids 6 to 20 of human CCR5.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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别名
- CCR5
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背景
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Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells.Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors.Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells.CCR5 is required for the infection by HIV-1, HIV-2, and SIV.The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1.CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells.The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites.CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
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分子量
- 40 kDa
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途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
抗原
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