IL1RAP 抗体 (AA 525-540)
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Quick Overview for IL1RAP 抗体 (AA 525-540) (ABIN1886887)
抗原
See all IL1RAP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 525-540
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交叉反应 (详细)
- This polyclonal antibody has no cross activity to other members in the IL-1 receptor family.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Peptide corresponding to amino acids 525 to 540 of human IL-1RAcP, which is identical to those of mouse and rat origins.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
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别名
- IL-1RAcP
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背景
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The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment.The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kappaB inducing kinae (NIK) and of NF-kappaB, recruits to the IL-1R complex through IL-1RAcP.IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP.Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response.IL-1RAcP is expressed in many tissues.
Synonyms: IL-1RAcP -
分子量
- 66 kDa
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途径
- NF-kappaB Signaling, Growth Factor Binding
抗原
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