BIRC7 抗体 (AA 264-280, AA 281-298)
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Quick Overview for BIRC7 抗体 (AA 264-280, AA 281-298) (ABIN1886863)
抗原
See all BIRC7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 264-280, AA 281-298
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特异性
- A lower but much weaker band at 30 kDa was detected in Raji cell lysate, which may represent the short form of Livin.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Livin antibody was raised with a Synthetic peptide corresponding to amino acids 264 to 280 of the short form and 281 to 298 of the long form of human Livin.This sequence is identical between a and b forms of the Livin proteins.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))
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别名
- Livin
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背景
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Apoptosis, or programmed cell death, is related to many diseases, such as cancer.Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins.IAP proteins form a conserved gene family that binds to and inhibits cell death proteases.A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP.Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-alpha and Livin-beta.Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6.Livin has direct interaction with several caspases including caspase-3, -7, and -9.Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP.The two isoforms of Livin appear to have different functions and tissue distributions.
Synonyms: KIAP -
分子量
- 33 kDa
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NCBI登录号
- NP_071444
抗原
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