E2F1 抗体 (AA 133-322)
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北京 101111
Quick Overview for E2F1 抗体 (AA 133-322) (ABIN1886014)
抗原
See all E2F1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 133-322
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 133 and 322 (Q01094) of E2F1
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- E2F1 (E2F Transcription Factor 1 (E2F1))
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别名
- E2F1
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背景
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The protein encoded by this gene is a member of the E2F family of transcription factors.The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.The E2F proteins contain several evolutionally conserved domains found in most members of the family.These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain.This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner.It can mediate both cell proliferation and p53-dependent/independent apoptosis.[provided by RefSeq]
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分子量
- 47 kDa
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基因ID
- 1869
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NCBI登录号
- NM_005225, NP_005216
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途径
- p53 Pathway, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy
抗原
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