Dual Specificity Phosphatase 3 (DUSP3) (AA 1-150) 抗体
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Quick Overview for Dual Specificity Phosphatase 3 (DUSP3) (AA 1-150) 抗体 (ABIN1885645)
抗原
See all Dual Specificity Phosphatase 3 (DUSP3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-150
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 150 of Human DUSP3
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Dual Specificity Phosphatase 3 (DUSP3)
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别名
- VHR
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背景
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The protein encoded by this gene is a member of the dualprotein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer.Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.[provided by RefSeq]
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分子量
- 20 kDa
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基因ID
- 1845
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NCBI登录号
- NP_004081, NM_004090
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途径
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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