Sonic Hedgehog 抗体 (AA 151-162)
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Quick Overview for Sonic Hedgehog 抗体 (AA 151-162) (ABIN1882186)
抗原
See all Sonic Hedgehog (SHH) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 151-162
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This shha antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 151-162 amino acids from the Central region of DANRE shha.
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord." in: Development (Cambridge, England), Vol. 126, Issue 10, pp. 2103-16, (1999) (PubMed).
: "Evolutionary analyses of hedgehog and Hoxd-10 genes in fish species closely related to the zebrafish." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 23, pp. 13036-41, (1996) (PubMed).
: "Patterning activities of vertebrate hedgehog proteins in the developing eye and brain." in: Current biology : CB, Vol. 5, Issue 8, pp. 944-55, (1995) (PubMed).
: "Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord." in: Cell, Vol. 76, Issue 4, pp. 761-75, (1994) (PubMed).
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: "Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord." in: Development (Cambridge, England), Vol. 126, Issue 10, pp. 2103-16, (1999) (PubMed).
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- Sonic Hedgehog (SHH)
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别名
- shha
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背景
- Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes. Displays floor plate-inducing activity. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).
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分子量
- 46403
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UniProt
- Q92008
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途径
- Hedgehog Signaling, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
抗原
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