Neuregulin 3 抗体 (AA 688-717)
(2 references)Quick Overview for Neuregulin 3 抗体 (AA 688-717) (ABIN1881587)
抗原
See all Neuregulin 3 (NRG3) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 688-717
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids of human NRG3.
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亚型
- IgG
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anti-Neuregulin 3 (NRG3) (Internal Region) antibody
NRG3 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (Internal Region) antibodyNRG3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) antibodyNRG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (AA 540-589) antibodyNRG3 适用: 人, 小鼠, 大鼠, 犬, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (AA 305-336) antibodyNRG3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1279-1280 unconjugated
anti-Neuregulin 3 (NRG3) (AA 351-450) antibodyNRG3 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (C-Term) antibodyVerified NRG3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (C-Term) antibodyNRG3 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (Middle Region) antibodyNRG3 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (AA 167-180), (Extracellular) antibodyNRG3 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Dynamic expression of Erbb pathway members during early mammary gland morphogenesis." in: The Journal of investigative dermatology, Vol. 128, Issue 4, pp. 1009-21, (2008) (PubMed).
: "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 18, pp. 9562-7, (1997) (PubMed).
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: "Dynamic expression of Erbb pathway members during early mammary gland morphogenesis." in: The Journal of investigative dermatology, Vol. 128, Issue 4, pp. 1009-21, (2008) (PubMed).
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- Neuregulin 3 (NRG3)
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别名
- NRG3
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背景
- NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.
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分子量
- 77901
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NCBI登录号
- NP_001010848, NP_001159445
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UniProt
- P56975
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途径
- RTK signaling
抗原
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