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TIM3 抗体 (AA 167-194)

This anti-TIM3 antibody is a 兔 多克隆 antibody detecting TIM3 in WB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN1881402
发货至: 中国

Quick Overview for TIM3 抗体 (AA 167-194) (ABIN1881402)

抗原

See all TIM3 (TIM 3) 抗体
TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

适用

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宿主

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克隆类型

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多克隆

标记

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This TIM3 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

RB41963
  • 抗原表位

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    AA 167-194

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This HAVCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-194 amino acids from the Central region of human HAVCR2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:2000. WB: 1:2000. WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Cao, Zhu, Zhu, Li, Zhang, Xu, Zhang: "Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer." in: Cancer immunology, immunotherapy : CII, Vol. 59, Issue 12, pp. 1851-7, (2010) (PubMed).

    Dorfman, Hornick, Shahsafaei, Freeman: "The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms." in: Human pathology, Vol. 41, Issue 10, pp. 1486-94, (2010) (PubMed).

    Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

    Dardalhon, Anderson, Karman, Apetoh, Chandwaskar, Lee, Cornejo, Nishi, Yamauchi, Quintana, Sobel, Hirashima, Kuchroo: "Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1383-92, (2010) (PubMed).

    Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, (2010) (PubMed).

  • 抗原

    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

    别名

    HAVCR2

    物质类

    Virus

    背景

    CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

    分子量

    33394

    NCBI登录号

    NP_116171

    UniProt

    Q8TDQ0

    途径

    Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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