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FADD 抗体 (AA 106-135)

Name: FADD 抗体 (AA 106-135)
SKU: ABIN1881331
Availability: OutOfStock

This anti-FADD antibody is a 兔多克隆 antibody detecting FADD in WB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.

FADD Antibody (Center) (ABIN1881331 and ABIN2838669) western blot analysis in WiDr cell line lysates (35 μg/lane). (FADD 抗体 (AA 106-135))

1 image

(5 references)

产品编号 ABIN1881331

发货至: 中国

Quick Overview for FADD 抗体 (AA 106-135) (ABIN1881331)

抗原

See all FADD 抗体

FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

适用

人

宿主

兔

克隆类型

多克隆

标记

This FADD antibody is un-conjugated

应用范围

Western Blotting (WB)

克隆位点

RB40884

Discover our top product FADD Primary Antibody

抗原表位
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7

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1

1

1

1

1

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1

1

1
AA 106-135

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.

亚型

Ig Fraction
anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 12-206) antibody
FADD 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 1-208) antibody
FADD 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 20-150) antibody
FADD 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5A6A2 unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 7-178) antibody
FADD 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 1-208) antibody
FADD 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 109-208) antibody
FADD 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C3 unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) antibody
FADD 适用: 小鼠 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 1-80) antibody
FADD 适用: 人, 小鼠, 大鼠, 猴, Pig WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (pSer191) antibody
FADD 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) antibody
FADD 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 5E8-A7 unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Papoff, Trivieri, Crielesi, Ruberti, Marsilio, Ruberti: "FADD-calmodulin interaction: a novel player in cell cycle regulation." in: Biochimica et biophysica acta, Vol. 1803, Issue 8, pp. 898-911, (2010) (PubMed).

Li, Jayarama, Ganesh, Mordi, Carr, Kanteti, Hay, Prabhakar: "Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22713-22, (2010) (PubMed).

Ko, Yang, Chung, Wen, Hsu, Miaw, Hsia: "Lack of Fas-pathway gene mutations in primary resected esophageal squamous cell carcinoma." in: Chang Gung medical journal, Vol. 33, Issue 2, pp. 145-51, (2010) (PubMed).

Hindryckx, De Vos, Jacques, Ferdinande, Peeters, Olievier, Bogaert, Brinkman, Vandenabeele, Elewaut, Laukens: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, (2010) (PubMed).

Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: "Dengue hemorrhagic fever is associated with polymorphisms in JAK1." in: European journal of human genetics : EJHG, Vol. 18, Issue 11, pp. 1221-7, (2010) (PubMed).
抗原

FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

别名

FADD

背景

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

分子量

23279

NCBI登录号

NP_003815

UniProt

Q13158

途径

Apoptosis, TLR signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades