我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

ERBB3 抗体 (pTyr1289)

Name: ERBB3 抗体 (pTyr1289)
SKU: ABIN1881314
Availability: OutOfStock

This anti-ERBB3 antibody is a 兔多克隆 antibody detecting ERBB3 in WB 和 DB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of extracts from T47D cells,untreated or treated with NRG using Phospho-ErBB3(Tyr1289)(left) or ErBB3 Antibody (right). (ERBB3 抗体 (pTyr1289))

Dot blot analysis of anti-Phospho-ERBB3 (Tyr1289) Antibody Phospho-specific Pab (ABIN1881314 and ABIN2839805) on nitrocellulose membrane. (ERBB3 抗体 (pTyr1289))

2 images

(5 references)

产品编号 ABIN1881314

发货至: 中国

Quick Overview for ERBB3 抗体 (pTyr1289) (ABIN1881314)

抗原

See all ERBB3 抗体

ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

适用

人

宿主

兔

克隆类型

多克隆

标记

This ERBB3 antibody is un-conjugated

应用范围

Western Blotting (WB), Dot Blot (DB)

克隆位点

RB25837

Discover our top product ERBB3 Primary Antibody

抗原表位
27

26

15

15

13

9

8

7

6

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr1289

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This ERBB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1289 of human ERBB3.

亚型

Ig Fraction
anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 707-964) antibody
ERBB3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55), (N-Term) antibody
ERBB3 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB01467 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1289) antibody
ERBB3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-130) antibody
ERBB3 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E9 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) antibody
ERBB3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 24-55) antibody
ERBB3 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (pTyr1328) antibody
ERBB3 适用: 人, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 661-760) antibody
ERBB3 适用: 人, 小鼠, 大鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 21-332) antibody
ERBB3 适用: 人 IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3F12 unconjugated

anti-Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (AA 1-131) antibody
ERBB3 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2E9 unconjugated

应用备注

WB: 1:1000. DB: 1:500

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Huang, Gao, Wang, McManaman, Thor, Yang, Esteva, Liu: "Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin." in: Cancer research, Vol. 70, Issue 3, pp. 1204-14, (2010) (PubMed).

Pierce, Ahsan: "Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk." in: Human heredity, Vol. 69, Issue 3, pp. 193-201, (2010) (PubMed).

Carr, Niederer, Williams, Harper, Watts, Lyons, Smith: "Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis." in: BMC medical genetics, Vol. 10, pp. 121, (2009) (PubMed).

Zhang, Opresko, Shankaran, Chrisler, Wiley, Resat: "HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells." in: BMC cell biology, Vol. 10, pp. 78, (2009) (PubMed).

Li, Feng, He: "Case-control study of association between the functional candidate gene ERBB3 and schizophrenia in Caucasian population." in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Vol. 10, Issue 4 Pt 2, pp. 595-8, (2009) (PubMed).
抗原

ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

别名

ERBB3

背景

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.

分子量

148098

NCBI登录号

NP_001005915, NP_001973

UniProt

P21860

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway