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BTRC 抗体 (N-Term)

Name: BTRC 抗体 (N-Term)
SKU: ABIN1881122
Availability: OutOfStock

This anti-BTRC antibody is a 兔多克隆 antibody detecting BTRC in WB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.

Anti-BTRC Antibody (N-term) at 1:1000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 μg per lane. (BTRC 抗体 (N-Term))

1 image

(5 references)

产品编号 ABIN1881122

发货至: 中国

Quick Overview for BTRC 抗体 (N-Term) (ABIN1881122)

抗原

See all BTRC 抗体

BTRC (beta-Transducin Repeat Containing (BTRC))

适用

人

宿主

兔

克隆类型

多克隆

标记

This BTRC antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product BTRC Primary Antibody

抗原表位
8

6

4

4

4

4

2

1

1

1

1

1
AA 127-156, N-Term

预测反应

M

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This BTRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the N-terminal region of human BTRC.

亚型

Ig Fraction
anti-beta-Transducin Repeat Containing (BTRC) (AA 24-151) antibody
BTRC 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 4C5D8 unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 50-340) antibody
BTRC 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) antibody
BTRC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 397-448) antibody
BTRC 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 1-605) antibody
BTRC 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (N-Term) antibody
BTRC 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 52-354) antibody
BTRC 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 2H2 unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 17-52), (N-Term) antibody
BTRC 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB16275 unconjugated

anti-beta-Transducin Repeat Containing (BTRC) antibody
BTRC 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 701-1000) antibody
BTRC 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Wan, Tang, Tytler, Lu, Jin, Vickers, Yang, Shi, Cao: "Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1." in: The Journal of biological chemistry, Vol. 279, Issue 15, pp. 14484-7, (2004) (PubMed).

Zhou, Deng, Xia, Xu, Li, Gunduz, Hung: "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition." in: Nature cell biology, Vol. 6, Issue 10, pp. 931-40, (2004) (PubMed).

Busino, Donzelli, Chiesa, Guardavaccaro, Ganoth, Dorrello, Hershko, Pagano, Draetta: "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage." in: Nature, Vol. 426, Issue 6962, pp. 87-91, (2003) (PubMed).

Yaron, Hatzubai, Davis, Lavon, Amit, Manning, Andersen, Mann, Mercurio, Ben-Neriah: "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase." in: Nature, Vol. 396, Issue 6711, pp. 590-4, (1999) (PubMed).

Margottin, Bour, Durand, Selig, Benichou, Richard, Thomas, Strebel, Benarous: "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif." in: Molecular cell, Vol. 1, Issue 4, pp. 565-74, (1998) (PubMed).
抗原

BTRC (beta-Transducin Repeat Containing (BTRC))

别名

BTRC

背景

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

分子量

68867

NCBI登录号

NP_003930, NP_378663

UniProt

Q9Y297

途径

Cell Division Cycle, Hedgehog Signaling