Western Blot: Use at 5-10 µg/ml using a human EDG-7 receptor transfected cell line. The optimal dilution for a specific application should be determined by the researcher.
限制
仅限研究用
缓冲液
Rabbit polyclonal antibody against human EDG-7 (CT). Available at 100 µg/100 µl in PBS with 0.08% sodium azide. Purification: Sterile filtered at 0.2 µm.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
EDG-7 belongs to a family of G-protein coupled receptors whose lignads are lysophospholipids. The ligand for EDG-7 sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-7 is expressed in prostate as well as other tissues.