S1PR1 抗体 (C-Term)
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北京 101111
Quick Overview for S1PR1 抗体 (C-Term) (ABIN187786)
抗原
See all S1PR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Reacts with human endothelial cell differentiation gene 1 (C-terminal), EDG-1. In Western blotting, detects an approximately 44 kDa band in RH7777 cells transfected with full length human EDG-1. For positive control, use RH7777 cells transfected with full length EDG-1. Species Reactivity: Human, other species not tested.
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过滤
- 0.2 μm filtered
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免疫原
- Synthetic peptide derived from the C-terminal of EDG-1 receptor.
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应用备注
- Western blotting: Use at 5-10 µg/ml using a human EDG-1 receptor transfected cell line. The optimal dilution for a specific application should be determined by the researcher.
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限制
- 仅限研究用
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缓冲液
- Rabbit polyclonal antibody against human endothelial cell differentiation gene 1 (CT). 100 µl of 1 mg/ml purified antibody 0.2 µm sterile filtered in phosphate buffered saline with 0.08% sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
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别名
- EDG-1 / S1P1
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背景
- EDG-1 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-1 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-1 is expressed in cardiovascular, leukocyte containing and other tissues.
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途径
- Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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