NOTCH2 抗体
Quick Overview for NOTCH2 抗体 (ABIN6796405)
抗原
See all NOTCH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes Notch 2, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Signalling through Notch 2 has been implicated in the development of marginal zone B cells (MZB), the sensitization of endothelial cells to apoptosis, and the regulation of the expression of CD23 in B-cell lymphocytic leukaemia (B-CLL). Studies have also shown a correlation between a decrease in Notch 2 expression and an increase in grade of human breast cancer. Clone HMN2-35 has been shown to cross-react with rat mast cell line RBL-2H3 and Y3 myeloma cells, in flow cytometry.
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纯化方法
- Protein G purified
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免疫原
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Mouse Notch 2-Fc fusion protein.
Type of Immunogen: Fusion protein -
亚型
- IgG
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anti-Notch 2 (NOTCH2) antibody
NOTCH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Asp1733), (cleaved) antibodyNOTCH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (C-Term) antibodyNOTCH2 适用: 人, 小鼠 WB, ChIP-seq 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 1501-1700) antibodyNOTCH2 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Asp1733) antibodyNOTCH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 59-250) antibodyNOTCH2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 2251-2466) antibodyNOTCH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 2242-2471) antibodyNOTCH2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Ala1734) antibodyNOTCH2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Target Species of Antibody: Mouse
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- NOTCH2 (Notch 2 (NOTCH2))
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别名
- NOTCH2 / NOTCH-2
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背景
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Name/Gene ID: NOTCH2
Synonyms: NOTCH2, AGS2, HN2, Notch (Drosophila) homolog 2, Notch homolog 2 (Drosophila), Notch 2, Notch homolog 2, HJCYS -
基因ID
- 4853
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UniProt
- Q04721
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途径
- Notch Signaling, Stem Cell Maintenance
抗原
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