P2RX7 抗体
Quick Overview for P2RX7 抗体 (ABIN6796397)
抗原
See all P2RX7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
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纯化方法
- Protein G purified
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免疫原
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A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Type of Immunogen: Cells -
亚型
- IgG2b
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anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (AA 226-452) antibody
P2RX7 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7G1D6 unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (Center) antibodyP2RX7 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (N-Term) antibodyP2RX7 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (AA 136-152), (Extracellular) antibodyKO Validated P2RX7 适用: 小鼠 WB, IHC, FACS, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (AA 136-152), (Extracellular) antibody (FITC)KO Validated P2RX7 适用: 小鼠 FACS, IF, IC, LCI 宿主: 兔 Polyclonal FITC
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (AA 47-334) antibodyP2RX7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (Internal Region) antibodyP2RX7 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (N-Term) antibodyVerified P2RX7 适用: 人, 小鼠 WB, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (C-Term) antibodyP2RX7 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (N-Term) antibodyP2RX7 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Approved: Flo (1:25 - 1:200), IF
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说明
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Target Species of Antibody: Mouse
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))
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别名
- P2RX7 / P2X7
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背景
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Name/Gene ID: P2RX7
Subfamily: P2X receptor
Family: Ion Channel
Synonyms: P2RX7, ATP receptor, p2X purinoceptor 7, p2X receptor 7, p2X7 purinoceptor, p2Z receptor, Purinergic receptor, p2RX7, p2X7, p2X7 receptor -
基因ID
- 5027
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UniProt
- Q99572
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis
抗原
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