IL23R 抗体 (AA 59-87)
Quick Overview for IL23R 抗体 (AA 59-87) (ABIN1819424)
抗原
See all IL23R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 59-87
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特异性
- Recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kD single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and possessing two domains. Multiple potential isoforms formed by alternative splicing are described. Recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), present in isoforms 1, 3 and 4, the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 and susceptibility to the ulcerative and inflammatory psoriasis. Is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues.
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纯化方法
- Affinity purified
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免疫原
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Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-terminal region of human IL-23 receptor. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan (100%), Marmoset, Dog (97%), Gibbon, Monkey, Panda (93%), Ferret, Bovine, Cat, Horse, Pig (90%).
Type of Immunogen: Synthetic peptide -
亚型
- IgG
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anti-Interleukin 23 Receptor (IL23R) (AA 405-629) antibody
IL23R 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) (AA 401-550) antibodyIL23R 适用: 人, 小鼠, 犬 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) (AA 15-125) antibodyIL23R 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) antibodyIL23R 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) (AA 25-355) antibodyIL23R 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) (N-Term) antibodyIL23R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) antibodyIL23R 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) antibodyIL23R 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) (N-Term) antibodyIL23R 适用: 人, 小鼠 WB, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Interleukin 23 Receptor (IL23R) (AA 553-628) antibodyIL23R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C12 unconjugated
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应用备注
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Approved: IHC, IHC-P (1:125), WB (1:500)
Usage: Use in IHC requires heat treatment prior to staining. -
说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, 0.1 % sodium azide, 0.1 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- IL23R (Interleukin 23 Receptor (IL23R))
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别名
- IL23R
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背景
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Name/Gene ID: IL23R
Family: Interleukin
Synonyms: IL23R, IL-23 receptor, Interleukin 23 receptor, IBD17, IL-23R, Interleukin-23 receptor -
基因ID
- 149233
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
抗原
-
