IGFBP3 抗体 (Biotin)
Quick Overview for IGFBP3 抗体 (Biotin) (ABIN181649)
抗原
See all IGFBP3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects Insulin-like Growth Factor Binding Protein 3.
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纯化方法
- Affinity chromatography
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免疫原
- Highly pure (> 98 %) recombinant human IGF-BP3
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anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 186-292) antibody
IGFBP3 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 182-291) antibodyIGFBP3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 162-189) antibodyIGFBP3 适用: 人, 小鼠, Hamster WB 宿主: 兔 Polyclonal RB28430 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 152-292) antibodyIGFBP3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 135-277) antibodyIGFBP3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D14 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 137-274) antibodyIGFBP3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 106-241) antibodyIGFBP3 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (Ser53) antibodyIGFBP3 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 1-291) antibodyIGFBP3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 100-200) antibodyIGFBP3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA: Direct: To detect hIGF-BP3 (using 100 μL/well antibody solution) a concentration of0.25 - 1.0 μg/mL of this antibody is required. In conjunction with compatible secondaryreagents, it allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIGF-BP3. Sandwich: To detect hIGF-BP3 (using 100 μL/well antibody solution) a concentration of
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限制
- 仅限研究用
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溶解方式
- Centrifuge vial prior to opening. Restore in sterile PBS containing 0.1 % BSA to a concentration of 0.1 - 1.0 mg/mL.
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缓冲液
- PBS, pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the lyophilized antibody at -20 °C. Following reconstitution it is stable for two weeks at 2 - 8 °C. Frozen aliquots are stable for 6 months when stored at -20 °C.
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有效期
- 6 months
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- IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))
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别名
- IGFBP3
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背景
- Insulin like growth factor binding protein 3 (IGFBP3) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The cDNA sequence encoding the mature human IGFBP3 is fused to the signal peptide of CD33. Human IGFBP3 is the major IGF binding protein in plasma where it exists in a ternary complex with IGFI or IGFII and an acid labile subunit. IGFBPs hold a central position in IGF ligand-receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. Insulin like growth factor binding protein 3 (IGFBP3) can modulate the mitogenic and metabolic effects of the insulin like growth factors (IGFs). Insulin like growth factor binding protein 3 (IGFBP3) is expressed in multiple tissues. The highest expression level is found in the non paranchymal cells of the liver. The expression levels are higher during extrauterine life and peak during puberty. Insulin like growth factors (IGFs) and IGF binding proteins (IGFBPs) play important roles in cell growth and differentiation. IGFBP3 is one of the factors in serum that is responsible for high serum induced apoptosis in PC3 cells, a prostate cancer cell line. IGFBP3 is important in controlling glucose homeostasis with increased urinary levels in type I diabetes with persistent microalbuminuria.Synonyms: IBP-3, IBP3, IGF-BP3, IGF-binding protein 3, IGFBP-3, Insulin-like growth factor-binding protein 3
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基因ID
- 3486
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NCBI登录号
- NP_000589
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UniProt
- P17936
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途径
- Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
抗原
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