ERK1/2 抗体
Quick Overview for ERK1/2 抗体 (ABIN1734127)
抗原
See all ERK1/2 (MAPK1/3) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Reacts with human Erk1 and Erk2. Cross-reacts with mouse, rat, chicken, sheep, bovine, drosophila and xenopus protein.
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纯化方法
- Serum
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免疫原
- 35 amino acid synthetic peptide corresponding to ERK1 conjugated to KLH.
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亚型
- IgG
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB1:5000
Positive control: HeLa cell -
限制
- 仅限研究用
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注意事项
- Dilute in PBS or medium which is identical to that used in the assay system.
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储存条件
- 4 °C/-20 °C
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储存方法
- Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.
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有效期
- 6 months
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- ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
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别名
- Erk1 + Erk2
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背景
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
Mitogen-activated protein kinase 3 & Mitogen-activated protein kinase 1 Extracellular signal-regulated kinase 1 & Extracellular signal-regulated kinase 3 ERK-1 & ERK-2 Gene name: MAPK3, MAPK1 -
UniProt
- P27361, P28482
抗原
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