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- 抗原 See all SYK 抗体
- SYK (Spleen tyrosine Kinase (SYK))
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抗原表位
- AA 296-484
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SYK antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of SYK (aa296-484) expressed in E. coli.
- 克隆位点
- 8C1A3
- 亚型
- IgG1
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- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
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Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions." in: Blood, Vol. 108, Issue 10, pp. 3352-9, (2006) (PubMed).
: "Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas." in: International journal of molecular medicine, Vol. 18, Issue 4, pp. 547-57, (2006) (PubMed).
: "Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells." in: The Journal of experimental medicine, Vol. 203, Issue 13, pp. 2829-40, (2006) (PubMed).
: "
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Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions." in: Blood, Vol. 108, Issue 10, pp. 3352-9, (2006) (PubMed).
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- 抗原
- SYK (Spleen tyrosine Kinase (SYK))
- 别名
- SYK (SYK 产品)
- 别名
- p72-Syk antibody, Sykb antibody, p72syk antibody, spleen associated tyrosine kinase antibody, spleen tyrosine kinase antibody, syk antibody, SYK antibody, Syk antibody
- 背景
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Description: SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.
Aliases: FLJ25043, FLJ37489, DKFZp313N1010
- 基因ID
- 6580
- HGNC
- 6580
- 途径
- Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
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