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SYK 抗体 (AA 296-484)

SYK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8C1A3 unconjugated
产品编号 ABIN1724704
发货至: 中国
  • 抗原 See all SYK 抗体
    SYK (Spleen tyrosine Kinase (SYK))
    抗原表位
    • 29
    • 22
    • 20
    • 13
    • 10
    • 10
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 296-484
    适用
    • 169
    • 82
    • 51
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    宿主
    • 158
    • 14
    • 3
    小鼠
    克隆类型
    • 161
    • 13
    单克隆
    标记
    • 101
    • 12
    • 10
    • 8
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    This SYK antibody is un-conjugated
    应用范围
    • 146
    • 83
    • 46
    • 26
    • 23
    • 19
    • 14
    • 14
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of SYK (aa296-484) expressed in E. coli.
    克隆位点
    8C1A3
    亚型
    IgG1
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Abbal, Lambelet, Bertaggia, Gerbex, Martinez, Arcaro, Schapira, Spertini: "Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions." in: Blood, Vol. 108, Issue 10, pp. 3352-9, (2006) (PubMed).

    Kunze, Wendt, Schlott: "Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas." in: International journal of molecular medicine, Vol. 18, Issue 4, pp. 547-57, (2006) (PubMed).

    Wossning, Herzog, Köhler, Meixlsperger, Kulathu, Mittler, Abe, Fuchs, Borkhardt, Jumaa: "Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells." in: The Journal of experimental medicine, Vol. 203, Issue 13, pp. 2829-40, (2006) (PubMed).

  • 抗原
    SYK (Spleen tyrosine Kinase (SYK))
    别名
    SYK (SYK 产品)
    别名
    p72-Syk antibody, Sykb antibody, p72syk antibody, spleen associated tyrosine kinase antibody, spleen tyrosine kinase antibody, syk antibody, SYK antibody, Syk antibody
    背景

    Description: SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

    Aliases: FLJ25043, FLJ37489, DKFZp313N1010

    基因ID
    6580
    HGNC
    6580
    途径
    Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
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