Working dilution: Optimal dilution should be determined by the end user. The following are guidelines only: WB2 μg/mL.
限制
仅限研究用
缓冲液
PBS, pH 7.4
注意事项
Dilute in PBS or medium that is identical to that used in the assay system.
储存条件
-20 °C
储存方法
Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
有效期
12 months
抗原
BCL3
(B-Cell CLL/lymphoma 3 (BCL3))
别名
Bcl-3
背景
The gene encoding Bcl-3 was first identified as the gene altered in some cases of chronic B cell lymphocytic leukemia and was later found to belong to the IκB subfamily of inhibitors of NFκB transcription factors. Bcl-3 does not have DNA-binding activity, but it interacts with NFκB1 and NFκB2 which, when bound to DNA, repress gene transcription. Therefore, Bcl-3 may promote gene expression that is repressed by members of the NFκB family. Bcl-3 RNA is highly expressed in spleen and liver with lower levels of expression in heart, skeletal muscle, lung, kidney, and testes.
B-cell lymphoma 3 protein homolog, BCL-3 Gene name: Bcl3