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p21 抗体 (AA 21-100)

Name: p21 抗体 (AA 21-100)
SKU: ABIN1714474
Availability: OutOfStock

Cited in 2+ publications. This 兔多克隆 anti-p21 antibody specifically detects p21 in WB, ELISA, FACS, IHC (p), IF (p), IF (cc), ICC 和 IHC (fro). The antibody is reactive with 人, 小鼠, 大鼠和绵羊 samples.

Human MG-63 lysates probed with Rabbit Anti-P21 Polyclonal Antibody, Unconjugated at 1:5000 for 90 min at 37˚C. (p21 抗体 (AA 21-100))

MCF-7 cells were stained with P21 Polyclonal Antibody, Unconjugated at 1:500 in PBS and incubated for two hours at 37°C followed by Goat Anti-Rabbit IgG (H+L) Cy3 conjugated secondary antibody. (p21 抗体 (AA 21-100))

IF (cc)

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-P21 Polyclonal Antibody, Unconjugated (ABIN1714474) at 1:200 followed by conjugation to the secondary antibody and DAB staining (p21 抗体 (AA 21-100))

IHC

3 images

(2 references)

产品编号 ABIN1714474

发货至: 中国

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中国
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Quick Overview for p21 抗体 (AA 21-100) (ABIN1714474)

抗原

See all p21 (CDKN1A) 抗体

p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

适用

人, 小鼠, 大鼠, 绵羊

宿主

兔

克隆类型

多克隆

标记

This p21 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

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AA 21-100

交叉反应

人, 小鼠, 大鼠, 绵羊

预测反应

Dog,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human P21

亚型

IgG
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 65-164) antibody
CDKN1A 适用: 人 WB, IF, ELISA, PLA 宿主: 小鼠 Monoclonal 2F1 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 1-164) antibody
CDKN1A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 1-100) antibody
CDKN1A 适用: Synthetic WB, IHC (f) 宿主: 兔 Monoclonal unconjugated Recombinant Antibody

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) antibody
CDKN1A 适用: 人, Non-Human Primate ELISA, IHC (p), ICC 宿主: 小鼠 Monoclonal WA-1 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (pThr145) antibody
CDKN1A 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) antibody
KD Validated CDKN1A 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 25GB3200 unconjugated Recombinant Antibody

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) antibody
CDKN1A 适用: 人 WB, IHC, IF, IHC (f) 宿主: 小鼠 Monoclonal CIP1-823 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 2-164) antibody
CDKN1A 适用: 人 IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (C-Term) antibody
CDKN1A 适用: 人, 小鼠, 大鼠 WB, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) antibody
CDKN1A 适用: 人 WB, IHC (f) 宿主: 兔 Monoclonal CIP1-2275R unconjugated Recombinant Antibody

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Wang, Cui, Wen, Guo, Zhang, Chen: "Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway." in: Oncology letters, Vol. 12, Issue 6, pp. 4605-4612, (2017) (PubMed).

Zhang, Tan, Wang, Chen, Quan, Xian, Zhang, He, Zhang: "Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway." in: Experimental cell research, Vol. 320, Issue 1, pp. 119-27, (2013) (PubMed).
抗原

p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

别名

P21

背景

Synonyms: P21, CIP1, SDI1, WAF1, CAP2, CDKN1, MDA-6, p21CIP1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, CDKN1A, MDA6, PIC1
Background: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

基因ID

1026

UniProt

P38936

途径

p53 Pathway, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy